Canicola fever - an acute infectious disease. It is characterized by an intoxication, a fever, a lesion of kidneys, a liver, nervous system and muscles. At serious forms the acute renal failure, an icterus and a hemorrhagic syndrome are observed. The becoming infected of the person occurs through the infected water, less often through foodstuff or at contact with infected animal (pigs, etc.).

Signs, current. The incubation interval lasts from 2 till 30 days (more often 7-10 days). Disease begins was acutely without any prodromal signs. There is a strong cold fit, the body temperature already in the first day reaches 39-40°С. Patients complain of a strong headache, a sleeplessness, absence of appetite, a muscular pain, especially in muscles calfs of legs. A pain in muscles so strong, that patients hardly can go. At a palpation the expressed morbidity of muscles is marked. The fever keeps 5-10 days, at some patients the second wave of a fever is observed. During same time at 20-50 % of patients the polymorphic exanthema (morbilliform, less often scarlatiniform) is marked. Serious forms are characterized by a hemorrhagic syndrome (hemorrhages in a sclera, ecchymoses in places of injections, nasal bleedings, etc.) . However there are serious forms a lethal outcome from a uremia at which are absent an icterus and displays of a hemorrhagic syndrome. About 45 days the augmentation of a liver and a lien is marked. The meningeal syndrome (more often owing to a serous meningitis) is possible.