Erythema nodulose - disease from group of deep angiites of the skin, shown in inflammatory units on the bottom extremities. The etiology is unknown.

Pathogenesis: a sensibilization of vessels of a skin and a hypodermic fat originators of various infectious diseases. Usually nodulose erythema develops after or on a background of the general infections (a streptococcal angina, a tuberculosis, a lepra, a lues, mycosises). Less often the sensitizing agent concerns to medicines. Quite often nodulose erythema happens a dermal syndrome of a sarcoidosis. Contributing factors: cold, developments of stagnation in the bottom extremities, an idiopathic hypertensia.

Distinguish the acute and chronic form. The acute nodulose erythema is shown by a fast rash on anticnemions of morbid bright red hydropic units in size up to a children's palm. Are marked a fever up to 38 - 39°С, the general delicacy, a headache, sometimes arthralgias. Units completely disappear in 2-3 weeks, consistently changing the painting on cyanotic, greenish, yellow (flowering of "ecchymosis"). Ulcerations of units do not happen. Disease meets at young women and children is more often, is usual after the transferred angina, does not recur. The chronic nodulose erythema (a nodulose angiitis) differs persistent relapsing current, arises mainly at women of an average and advanced age quite often aggravated by the general vascular or allergic diseases, the centers of a chronic infection. Exacerbations arise in the spring and in the autumn is more often, are characterized by occurrence of a small number of inflammatory dense moderately morbid units of corporal or is cyanotic-pink color, size with wood or a walnut. The basic localization - anticnemions, less often than a femur. Puffiness of the bottom extremities is often observed.