Hemolitic illness of newborns - the illness caused by the immunologic conflict between mother and a fetus from-занесовместимости on erythrocyte antigens.

Etiology. Illness develops owing to incompatibility of a blood of a fetus and mother on antigens.

Pathogenesis. Any of the specified antigens (more often a rhesus of antibodies), getting into a blood of Rh-negative mother, causes formation in its organism of specific antibodies. The last through a placenta act in a blood of a fetus where blast containing erythrocytes corresponding an antigen.

The icteric form - the most frequent clinical form; it is shown for 1-2 day of a life of the child. The icterus, augmentation of a liver and a lien are marked. Children flaccid, adynamic, badly suck. Reflexes are lowered. Urine dark, a feces of usual painting. In the further can raise and the maintenance of a direct bilirubin. Then there are classical attributes of a nuclear icterus: a muscular hypertonus, a stiff neck, sharp "cerebral" cry, a hyperesthesia, a protrusion of the big fontanel, twitching of muscles, cramps, a positive sign of the coming sun, a nystagmus and full respiratory standstill. In 2-3 weeks the condition of the patient improves, however in the subsequent attributes children's cerebral a paralysis (an athetosis, a choreoathetosis, paralyses, paresises, a delay of psychophysical development, deafness, a dysarthtia, etc.) are taped.

The anemic form - the most good-quality, meets in 10-15 % of cases and is shown by paleness, bad appetite, a flaccidity, augmentation of a liver and a lien, an anemia, the moderate rising of a bilirubin.