Premenstrual syndrome - a complex of the mental, vegetative vascular and metabolic endocrine signs appearing for 7-10 days prior to a menses and disappearing with its beginning. In the age of 19-29 years the premenstrual syndrome is observed at 20 % of women, in 30-40 years - at 47 %, in 41-50 years (at a regular menstrual cycle) - up to 55 %. More often this syndrome is observed at the women borrowed by intellectual work, and also at emotionally labile women.

The etiology, pathogenesis are studied insufficiently. Theories of disturbance of the hormonal homeostasis, explaining occurrence of a premenstrual syndrome on a background of an anovulation or a failure of a yellow body (weakly expressed in the second phase of a menstrual cycle), are Most widespread by disturbance of secretion and a metabolism of Aldosteronum, a renin, an angiotensin, a serotonin.