Renal not a diabetes mellitis - hereditary disease at which kidneys are not capable to produce urine with higher concentration, than an osmolarity of a glomerular ultrafiltrate of plasma that is bound to an anesthesia of renal canaliculuses to an antidiuretic hormone. Nephrogenic not the diabetes mellitis should be distinguished from neuronic at which reactions of kidneys to an antidiuretic hormone are kept, but processes of subthalamic neuronic secretion are broken.

At nephrogenic not a diabetes mellitis the homeostatic function of kidneys referred on conservation of water-salt equilibrium is considerably broken. It conducts to appreciable fluctuations of osmotic pressure of a blood plasma and a hyperelectrolytemia: concentration of sodium in plasma can raise. These fluctuations at children of early age at whom the feeling of thirst is not developed are especially great. Losses of significant amounts of water conduct to development of a dehydration, a toxicosis.

Clinical picture. Disease is shown on 3-6 month of a life by a plentiful diuresis, a vomiting, predilection to a constipation, a feverish condition. The feeling of thirst can be absent. The volume of daily urine of the baby can reach 2 litres, in more advanced age - 5-10 litres.

« The saline fever » is observed, convulsive conditions are possible. Proof disturbances of water-salt balance can lead to development of an oligotrophy, a delay physical, and at some children and mental development. At sufficient introduction of a liquid of it it is not observed.